Cytochrome P450 Part 3: Impact of Drug-Drug Interactions
نویسندگان
چکیده
منابع مشابه
Cytochrome P450 enzyme mediated herbal drug interactions (Part 1)
It is well recognized that herbal supplements or herbal medicines are now commonly used. As many patients taking prescription medications are concomitantly using herbal supplements, there is considerable risk for adverse herbal drug interactions. Such interactions can enhance the risk for an individual patient, especially with regard to drugs with a narrow therapeutic index such as warfarin, cy...
متن کاملCytochrome P450 enzyme mediated herbal drug interactions (Part 2)
To date, a number of significant herbal drug interactions have their origins in the alteration of cytochrome P450 (CYP) activity by various phytochemicals. Among the most noteworthy are those involving St. John's wort and drugs metabolized by human CYP3A4 enzyme. This review article is the continued work from our previous article (Part 1) published in this journal (Wanwimolruk and Prachayasitti...
متن کاملRole of cytochrome P450 in drug interactions
Drug-drug interactions have become an important issue in health care. It is now realized that many drug-drug interactions can be explained by alterations in the metabolic enzymes that are present in the liver and other extra-hepatic tissues. Many of the major pharmacokinetic interactions between drugs are due to hepatic cytochrome P450 (P450 or CYP) enzymes being affected by previous administra...
متن کاملEffects of Tenapanor on Cytochrome P450‐Mediated Drug‐Drug Interactions
Tenapanor (RDX5791, AZD1722) is an inhibitor of sodium/hydrogen exchanger isoform 3 in development for the treatment of constipation-predominant irritable bowel syndrome and the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis. We aimed to investigate whether tenapanor inhibits or induces cytochrome P450s (CYPs). In vitro experiments assessing the potential of ...
متن کاملDrug-associated disease: cytochrome P450 interactions.
Critically ill patients generally are older, frequently have organ failure, and commonly receive multiple medications, all of which make them susceptible to adverse effects of drugs. Drug interactions are a common adverse effect, and many are predictable based on understanding the mechanisms that underlie drug interactions. This article identifies commonly used medications in critically ill pat...
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ژورنال
عنوان ژورنال: Journal of Pharmacy Practice and Research
سال: 2009
ISSN: 1445-937X
DOI: 10.1002/j.2055-2335.2009.tb00705.x